2013年8月2日星期五

Look where 3D printing can get you headlights Led Luminaries

Look where 3D printing can get you headlights Led Luminaries

2013/08/01

07aug13BlogLamp.jpg

Not sure if this bicycle light has been made or is just excellent rendering of a CAD design.

Either way, the case it ready to be made in a 3D printer, and shows how straightforward making a prototype could be.

More information on Thingiverse.

Bet those heatsinks get warm after a while.


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SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

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2013年8月1日星期四

'Evolution will punish you if you're selfish and mean'

'Evolution will punish you if you're selfish and mean'

Aug. 1, 2013 — Two Michigan State University evolutionary biologists offer new evidence that evolution doesn't favor the selfish, disproving a theory popularized in 2012.


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"We found evolution will punish you if you're selfish and mean," said lead author Christoph Adami, MSU professor of microbiology and molecular genetics. "For a short time and against a specific set of opponents, some selfish organisms may come out ahead. But selfishness isn't evolutionarily sustainable."

The paper appears in the current issue of Nature Communications and focuses on game theory, which is used in biology, economics, political science and other disciplines. Much of the last 30 years of research has focused on how cooperation came to be, since it's found in many forms of life, from single-cell organisms to people.

In 2012, a scientific paper unveiled a newly discovered strategy -- called zero-determinant -- that gave selfish players a guaranteed way to beat cooperative players.

"The paper caused quite a stir," said Adami, who co-authored the paper with Arend Hintze, molecular and microbiology research associate. "The main result appeared to be completely new, despite 30 years of intense research in this area."

Adami and Hintze had their doubts about whether following a zero determinant strategy (ZD) would essentially eliminate cooperation and create a world full of selfish beings. So they used high-powered computing to run hundreds of thousands of games and found ZD strategies can never be the product of evolution. While ZD strategies offer advantages when they're used against non-ZD opponents, they don't work well against other ZD opponents.

"In an evolutionary setting, with populations of strategies, you need extra information to distinguish each other," Adami said.

So ZD strategies only worked if players knew who their opponents were and adapted their strategies accordingly. A ZD player would play one way against another ZD player and a different way against a cooperative player.

"The only way ZD strategists could survive would be if they could recognize their opponents," Hintze said. "And even if ZD strategists kept winning so that only ZD strategists were left, in the long run they would have to evolve away from being ZD and become more cooperative. So they wouldn't be ZD strategists anymore."



Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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Passives IP67 connectors are tough for industry and vehicles

Passives IP67 connectors are tough for industry and vehicles

2013/08/01

Molex has introduced an industrial connector family that exceed IP67 and can be submerged in various fluids.

Called MX150L, it “supports low-level signals as well as power applications up to 40A”, said the firm. “Customers can choose from wire-to-wire, wire-to-panel and wire-to-board configurations and a wide range of wire styles and insulation thicknesses.”

Applications are expected in commercial vehicles, marine equipment and industrial equipment, particularly industrial power modules.

That said, not all automotive applications are covered.

“While MX150L connectors exceed IP67 requirements and conform to UL 1977, they are not designed for automotive applications with requirements such as USCAR-2, USCAR-25, GMW3191, AK Testing, J2030, Volvo Technology Requirements and Toyota Connector Spec [TCS], warned Molex.

Housings and terminal position assurance [TPA] components are pre-assembled and shipped in one piece

“The integral TPA provides a secondary lock to keep terminals in place and optional connector position assurance [CPA] components prevent accidental disconnection if the connector latch is depressed,” said the firm. To assemble, the appropriate terminal is crimped, inserted, then the TPA is engaged to its locked position “with no additional assembly steps required. Audible and tactile clicks on insertion, extraction and mating facilitate reliable mating and terminal loading and removal.”

The matt seal is a single silicone-based piece with individual wire openings, and a cap to protect, retain the seal as well as provide strain relief to the assembly.

Connections are based on 1.5 and 2.5mm blade-type terminals “which eliminate the need to purchase, handle and crimp individual wire seals and help reduce labour costs”, claimed Molex.

There are tools for high-volume production, low-volume production, and field repairs.


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SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

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SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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Hot-plugging and ceramic caps team up to ruin your circuit General An Engineer In Wonderland

Hot-plugging and ceramic caps team up to ruin your circuit General An Engineer In Wonderland

2013/08/01

Linear Tech has written an application note to warn warn of the potential hazard of using ceramic caps for equipment input decoupling if long leads are involved.

The danger comes from the wonderful low impedance of these capacitors, resonating with power lead inductance.

If a voltage step is applied – for example when plugging an already-energised wall adapter into something to charge it – a spike can be generated with far more amplitude than the voltage applied, and with enough energy to take out parts of the decoupled circuit.

Read Linear Tech app note 88, “Ceramic input capacitors can cause overvoltage transients”.


Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

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University of St Andrews looks to Scotland’s Digital Future’ General, University of St Andrews Universities - Electronics Research

University of St Andrews looks to Scotland’s Digital Future’ General, University of St Andrews Universities - Electronics Research

August 1, 2013

Steve Watt, chief information officer at the University, was voted ICT Leader of the Year at the 2013 Holyrood Connect ICT Awards.

At the same ceremony in Glasgow, the St Andrews department also won the Green Award – for “effective use of ICT to deliver environmental benefits.”

“IT provision in universities and the public sector is changing dramatically – and we need to embrace ‘Scotland’s Digital Future’ – supporting the transition to a world-leading digital economy,” said Watt.

The University of St Andrews, which is celebrating its 600th anniversary this year, is committed to reducing its carbon footprint.

IT power management has a significant part to play in this. Around 30% of the electricity consumed by the University is used to power ICT equipment, with a large proportion powered 24 hours-a-day.

The University’s new data centre saves the institution at least £65k per year on its electricity bills.

Watt, who is leading a project to revitalise the St Andrews IT Services, had competition from candidates from Edinburgh City Libraries, Edinburgh Napier University and the Crown Office.


Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.


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Wall chargers and ceramic caps team up to ruin your circuit General An Engineer In Wonderland

Wall chargers and ceramic caps team up to ruin your circuit General An Engineer In Wonderland

2013/08/01

Linear Tech has written an application note to warn warn of potential hazard when using ceramic caps for equipment input decoupling if long supply leads are involved.

Danger comes from the wonderful low resistance and inductance of these capacitors, which allows the capacitance to resonate at high frequency with power lead inductance.

If a voltage step is applied – for example when plugging an already-energised wall adapter into the circuit – a spike can be generated with far more amplitude than the voltage applied, and with enough energy to take out parts of the decoupled circuit.

Read Linear Tech app note 88, “Ceramic input capacitors can cause overvoltage transients”.

Moving to a capacitor with a higher ESR, or adding a resistor of a fraction of an ohm in series with the input, is the answer.


Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

Electronic Components distributor:http://www.suvsystem.com

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SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.


AVX Resistors Switches TDK IC ROHM Resistors Bipolar Transistors Zener Diodes IC(Integrated Circuits) Cypress IC Schottky Diodes Atmel IC Chip Ferrite Beads Fairchild Semiconductor Transistors Capacitor TOSHIBA Diodes PANASONIC Resistors Voltage Regulators Transistors INFLNEON Diodes NXP Diodes ALTERA IC INTERSIL IC Renesas parts IC Thick Film Resistors SANYO IC LINEAR IC MOTOROLA IC High Precision Resistors ON Transistors VISHAY IC Resistor Arrays Switching Diodes YAGEO Resistors components Resistors DIODES Transistors Fleld Effect Transistors Freescale Semiconductor Industrial IC IR Diodes Kingbrigt LED NS IC
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Business NXP sees sales growth as mixed-signal business jumps

Business NXP sees sales growth as mixed-signal business jumps

2013/08/01

19jun13NxpBLF25M612G 346NXP Semiconductors has reprted a 9% increase in second quarter revenues, both month-on-month and year-on-year.

Q2 revenues were $1.188bn.

“Our revenue performance during the quarter reflected robust double digit sequential growth across all of our high performance mixed-signal (HPMS) end-markets with a strong rebound in growth in our Infrastructure & Industrial and our Portable & Computing business,” said  Richard Clemmer, NXP Chief Executive Officer.

The chip firm’s ID and chipcard business saw strong ongoing demand in banking and transport markets.

“Our automotive business delivered strong sequential growth due to better than seasonal demand, combined with the launch of a new customer entertainment programme and the continued ramp of major keyless entry programmes,” said Clemmer.

The standard products business continues to disappoint with  weaker than expected demand for certain logic products within the mobile end-market.

“The overall performance of HPMS is very good, with operating margin solidly within our long-term target, and we are comfortable delivering on our intermediate profitability goals,” said Clemmer.

NXP expects Q3 revenues to be in the range $1.24bn to $1.286bn.

Total debt at the end of the second quarter was $3.38bn, a $59m reduction from the prior quarter.

Cash at the end of the second quarter of 2013 was $569 million, resulting in a net-debt position of $2,812 million, a $33 million reduction from the prior quarter.

Fab utilisation was slightly down on a year ago at 90% in the second quarter, but better than in the prior quarter.


Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.


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Business 4G ready to go; O2 announces launch date; others vague.

Business 4G ready to go; O2 announces launch date; others vague.

2013/08/01

As of this morning, the spectrum allocated for 4G is cleared for action and O2 announced today that it will start a limited 4G service in three cities London, Bradford and Leeds on August 29th.

Vodafone, Three and BT, which also bought licences to use 4G spectrum five months ago, are still vague about the dates for launching their 4G services.

O2 says it will cover ten cities by the end of the year.

The spectrum licensed for 4G is in the 800MHz and 2.6GHz bands. It was bought by Vodafone, O2, Three, BT  and EE.

However EE got a flying start when it got Ofcom’s go-ahead to use some of its existing 1800MHz spectrum, bought for 3G services, to launch a 4G service.

Vodafone is saying it will launch 4G services sometime in the summer, and Three is saying it will launch 4G services in Q4.

Analogue TV was broadcast over the spectrum which is now ready to be used by the wireless network companies.


Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.


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Business Blu Wireless raises $3.1m

Business Blu Wireless raises $3.1m

2013/08/01

60GHz wireless specialist, Blu Wireless has closed a $3.1 million funding round. This will allow the company to drive further growth, doubling in size to 30 staff, and complete the development of its HYDRA baseband IP offering for 802.11ad next generation WiFi (WiGig CERTIFIED) and 4G mobile network backhaul applications.

The funding round was led by Qi3 Accelerator, who represented a syndicate of over $1.5m (£1m) of London Business Angels private investors, including Wren Capital. A further $0.9 million (£0.6m) was invested by the Angel Co-Fund, several additional investors made up the remainder.

Blu Wireless’s baseband technology uses a flexible parallel processing architecture to efficiently support the complex modulation schemes required for emerging multi-gigabit wireless communication standards. The IP is currently optimised for chipsets used in both advanced WiFi and 4G small cell deployments, and can be simply scaled to support the anticipated future standards as they move to 20Gbps and beyond.

The Bristol, UK based firm is already working with several of the world’s leading semiconductor and system companies in these markets.

The IP will be sold under license agreement to chipset manufacturers that compete in, or want to enter, markets that exploit the unlicensed 60GHz frequency band.

Blu Wireless’s CEO, Henry Nurser commented: “With the completion of this funding round, we will be executing our plan to become the leading supplier of baseband system IP to manufacturers in the 60GHz sector.”


Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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Spitzer Discovers Young Stars with a 'Hula Hoop'

Spitzer Discovers Young Stars with a 'Hula Hoop'

As the two inner stars whirl around each other, they periodically peek out from the disk that girds them like a hula hoop. The hoop itself appears to be misaligned from the central star pair, probably due to the disrupting gravitational presence of the third star orbiting at the periphery of the system. The whole system cycles through bright and faint phases, with the central stars playing a sort of cosmic peek-a-boo as the tilted disk twirls around them. It is believed that this disk should go on to spawn planets and the other celestial bodies that make up a solar system.

Spitzer observed infrared light from YLW 16A, emitted by the warmed gas and dust in the disk that still swathes the young stars. Other observations came from the ground-based 2MASS survey, as well as from the NACO instrument at the European Southern Observatory's Very Large Telescope in Chile.

YLW 16A is the fourth example of a star system known to blink in such a manner, and the second in the same star-forming region Rho Ophiuchus. The finding suggests that these systems might be more common than once thought. Blinking star systems with warped disks offer scientists a way to study how planets form in these environments. The planets can orbit one or both of the stars in the binary star system. The famous science fictional planet Tatooine in "Star Wars" orbits two stars, hence its double sunsets. Such worlds are referred to as circumbinary planets. Astronomers can record how light is absorbed by planet-forming disks during the bright and faint phases of blinking stellar systems, which in turn reveals information about the materials that comprise the disk.

"These blinking systems offer natural probes of the binary and circumbinary planet formation process," said Peter Plavchan, a scientist at the NASA Exoplanet Science Institute and Infrared Processing and Analysis Center at the California Institute of Technology, Pasadena, Calif., and lead author of a new paper accepted for publication in Astronomy & Astrophysics.

NASA's Jet Propulsion Laboratory, Pasadena, Calif., manages the Spitzer Space Telescope mission for NASA's Science Mission Directorate, Washington. Science operations are conducted at the Spitzer Science Center at Caltech. Data are archived at the Infrared Science Archive housed at the Infrared Processing and Analysis Center. Caltech manages JPL for NASA. For more information about Spitzer, visit http://spitzer.caltech.edu and http://www.nasa.gov/spitzer .


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NASA's Cassini sees forces controlling Enceladus jets

NASA's Cassini sees forces controlling Enceladus jets

July 31, 2013 — The intensity of the jets of water ice and organic particles that shoot out from Saturn's moon Enceladus depends on the moon's proximity to the ringed planet, according to data obtained by NASA's Cassini spacecraft.


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The finding adds to evidence that a liquid water reservoir or ocean lurks under the icy surface of the moon. This is the first clear observation the bright plume emanating from Enceladus' south pole varies predictably. The findings are detailed in a scientific paper in this week's edition of Nature.

"The jets of Enceladus apparently work like adjustable garden hose nozzles," said Matt Hedman, the paper's lead author and a Cassini team scientist based at Cornell University in Ithaca, N.Y. "The nozzles are almost closed when Enceladus is closer to Saturn and are most open when the moon is farthest away. We think this has to do with how Saturn squeezes and releases the moon with its gravity."

Cassini, which has been orbiting Saturn since 2004, discovered the jets that form the plume in 2005. The water ice and organic particles spray out from several narrow fissures nicknamed "tiger stripes."

"The way the jets react so responsively to changing stresses on Enceladus suggests they have their origins in a large body of liquid water," said Christophe Sotin, a co-author and Cassini team member at NASA's Jet Propulsion Laboratory in Pasadena, Calif. "Liquid water was key to the development of life on Earth, so these discoveries whet the appetite to know whether life exists everywhere water is present."

For years scientists hypothesized the intensity of the jets likely varied over time, but no one had been able to show they changed in a recognizable pattern. Hedman and colleagues were able to see the changes by examining infrared data of the plume as a whole, obtained by Cassini's visual and infrared mapping spectrometer (VIMS), and looking at data gathered over a long period of time.

The VIMS instrument, which enables the analysis of a wide range of data including the hydrocarbon composition of the surface of another Saturnian moon, Titan, and the seismological signs of Saturn's vibrations in its rings, collected more than 200 images of the Enceladus plume from 2005 to 2012.

These data show the plume was dimmest when the moon was at the closest point in its orbit to Saturn. The plume gradually brightened until Enceladus was at the most distant point, where it was three to four times brighter than the dimmest detection. This is comparable to moving from a dim hallway into a brightly lit office.

Adding the brightness data to previous models of how Saturn squeezes Enceladus, the scientists deduced the stronger gravitational squeeze near the planet reduces the opening of the tiger stripes and the amount of material spraying out. They think the relaxing of Saturn's gravity farther away from planet allows the tiger stripes to be more open and for the spray to escape in larger quantities.

"Cassini's time at Saturn has shown us how active and kaleidoscopic this planet, its rings and its moons are," said Linda Spilker, Cassini project scientist at JPL. "We've come a long way from the placid-looking Saturn that Galileo first spied through his telescope. We hope to learn more about the forces at work here as a microcosm for how our solar system formed."

The Cassini-Huygens mission is a cooperative project of NASA, the European Space Agency and the Italian Space Agency. JPL, a division of the California Institute of Technology, Pasadena, manages the mission for NASA's Science Mission Directorate in Washington. The VIMS team is based at the University of Arizona in Tucson.

For more information about the Cassini mission, visit: http://www.nasa.gov/cassini and http://saturn.jpl.nasa.gov .



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New protein discovered with vast potential for treatment of cancer and other diseases

New protein discovered with vast potential for treatment of cancer and other diseases

The identification of CPTP was the result of an international collaboration that built on prior research by co-lead author Charles Chalfant, Ph.D., Endowed Chair of Cancer Cell Signaling and member of the Cancer Cell Signaling program at Virginia Commonwealth University Massey Cancer Center as well as professor in the Department of Biochemistry and Molecular Biology at VCU School of Medicine. The team discovered that CPTP regulates levels of biologically active lipids, which are molecules such as fatty acids that often play a role in cell signaling. As its name implies, this study determined that CPTP's main function is to transport ceramide-1-phosphate (C1P), a lipid that helps regulate cell growth, survival, migration and inflammation. Specifically, C1P increases the production of pro-inflammatory eicosanoids -- powerful signaling molecules that contribute to chronic inflammation in diseases such as cancer, asthma, atherosclerosis and thrombosis -- and the discovery of CPTP shines a light on the cellular mechanisms that contribute to these diseases.

"We may have identified the newest target for treating cancer," says Chalfant. "Because of the important role this protein plays in a number of cellular functions, it could also have large implications for a variety of diseases like cancer that are caused by inflammation."

With assistance from Massey's Lipidomics Developing Shared Resource core, the researchers were able to determine the composition of the bioactive lipids regulated by CPTP. Residing in the cytosol, or the liquid within cells, the team found that CPTP regulates catabolism of C1P, a process that breaks down the molecule in order to release its energy. They also demonstrated that CPTP transports C1P to the cellular membrane where it helps synthesize eicosanoids from fatty acids in the membrane.

Confirming a decade of research from Chalfant's laboratory, the scientists provided further proof that C1P regulates group IVA phospholipase A2, an enzyme that promotes inflammation through the production of a fatty acid known as arachidonic acid. The release of arachidonic acid via C1P activation of this enzyme was shown to trigger the production of eicosanoids. These findings help to explain the reported link between ceramide kinase, the enzyme responsible for C1P production, and poor prognosis in breast cancer patients, which further suggests that alleviation of systemic inflammation may lead to better prognosis and better treatment responses.

"Moving forward, we hope to use our knowledge of the structure of CPTP in order to find small molecules and other means that can block it," says Chalfant. "The immediate uses of such therapeutics might be to restore clotting in trauma patients by maintaining the levels of specific eicosanoids that mediate blood clotting. However, with further research we hope to define exactly how CPTP is produced so that we can regulate its production and potentially develop new treatments for a variety of diseases."


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